Exposure to particles in industry and mining and from accidental anthropogenic sources constitutes an ongoing threat. Most recently nanoparticles arising from advances in technology are exposing a wider population to pathogenic stimuli. The effects of inhaled particles are no longer confined to the lung as nanoparticles have the potential to translocate to the bloodstream, the brain, and other target sites. The new questions posed by nanoparticles underscore the importance of interdisciplinary research and exchange and highlight the need for new collaborations among disciplines in medicine, toxicology, chemistry, and material sciences. Particle Toxicology brings together the state of the science in particle physico-chemistry, cell biology, and toxicology in a single volume. While organized around the classical toxicology paradigm of exposure - dose - response, the book is unique in its emphasis on mechanistic toxicology. Preparing the reader with a brief historical overview and a conceptual framework for particle research, the book provides reviews on the mechanisms and properties of pathogenic particles and their effects on target cells at various sites in the body. The text describes how adverse effects are a consequence of deposition, translocation, and the complex issue of "dose" dominates. Contributions from leading researchers address particle-associated pro-inflammatory effects and inflammatory signaling, cellular and extracellular oxidative and nitrosative stress, particulate interactions in the pulmonary, cardiovascular, and central nervous systems, as well as genotoxic effects. Exemplar particles include quartz, asbestos, particulate material and nanoparticles. The book also covers mathematical modeling and human studies as avenues for future research. Responding to the evolving trend of consumer applications for particulate matter, Particle Toxicology provides the comprehensive resource for current knowledge from which to develop ne

Exposure to particles in industry and mining and from accidental anthropogenic sources constitutes an ongoing threat. Most recently nanoparticles arising from advances in technology are exposing a wider population to pathogenic stimuli. The effects of inhaled particles are no longer confined to the lung as nanoparticles have the potential to translocate to the bloodstream, the brain, and other target sites. The new questions posed by nanoparticles underscore the importance of interdisciplinary research and exchange and highlight the need for new collaborations among disciplines in medicine, toxicology, chemistry, and material sciences. Particle Toxicology brings together the state of the science in particle physico-chemistry, cell biology, and toxicology in a single volume. While organized around the classical toxicology paradigm of exposure - dose - response, the book is unique in its emphasis on mechanistic toxicology. Preparing the reader with a brief historical overview and a conceptual framework for particle research, the book provides reviews on the mechanisms and properties of pathogenic particles and their effects on target cells at various sites in the body. The text describes how adverse effects are a consequence of deposition, translocation, and the complex issue of "dose" dominates. Contributions from leading researchers address particle-associated pro-inflammatory effects and inflammatory signaling, cellular and extracellular oxidative and nitrosative stress, particulate interactions in the pulmonary, cardiovascular, and central nervous systems, as well as genotoxic effects. Exemplar particles include quartz, asbestos, particulate material and nanoparticles. The book also covers mathematical modeling and human studies as avenues for future research. Responding to the evolving trend of consumer applications for particulate matter, Particle Toxicology provides the comprehensive resource for current knowledge from which to develop ne

Gathering together thoughts and visions of experienced practitioners, academics, educators and strategic leaders from around the world, this edited volume sheds light on the nature of chaplaincy and its role and significance within ever-changing contemporary healthcare systems. A wide range of issues central to spiritual care delivery are covered, including reflections on what it feels like to be cared for by a chaplain through illness; the nature of chaplaincy as a profession; and how chaplains can engage with healthcare institutions in ways that have integrity yet are also deeply spiritual. The focus throughout is that chaplaincy should not only be guidance for people in distress, as a form of crisis intervention, but is rather about helping to promote wellbeing and enhance people's quality of life. Where specialisms tend to fragment systems and individuals, this book seeks to show that true health and wellbeing can only be found through a holistic approach, and shows how chaplaincy can bring this to the table. This book is for anyone who recognises the centrality of spirituality for wellbeing, and wishes to see what that might look like in practice.

Life-forms of another kind lurk in the shadows once watching and waiting from another dimension across space beyond the barriers of time fuelled with hunger for our resources begin to come forth. In what will be a battle for supremacy against a new force humans have no idea existed until one massive intergalactic war changes history where humanity now fights for its own right to survive.

Legend of old, speaks tales of betrayal, in a world of sorcery where greater powers of unknown forces offer promises for a heavy price.

In the Summer, every Mouse dreams of adventure, treasures and becoming the hero too. Welcome to BeaverGully, a quaint place where one such mouse dreaming of adventures untold and all the treasures any mouse could ever want soon finds himself taking a magical journey with you

Her winter fling in the land of his summer. One seeking love the other locked on a path of desintys? calling, becomes a dangerous liaison between two destinies across time's continuum. Upon Alice's return everything from the year before had now evolved in ways she was not expecting as her personal interests open an unexpected surprising discovery even she never would have imagined.